Take a deeper look into all the publications produced by researchers at The Dartmouth Institute.

Dannenberg MD, Durand MA, Montori VM, Reilly C, Elwyn G

2018 Jun 18;pii: S0895-4356(17)31196-4. doi: 10.1016/j.jclinepi.2018.06.003

Our aim was to evaluate how organizations that develop patient decision aids conduct their evidence summarization process and assess whether their current processes provide sufficient information to instill confidence that patient decision aids are trustworthy and up-to-date STUDY DESIGN AND SETTING: : We identified 23 organizations from a public inventory of patient decision aid developers and included only organizations that have produced five or more tools. These organizations were asked to complete a 17-item survey and to share relevant documents.

J Clin Epidemiol|2018 Jun 18

Ko M, Mendecki L, Mirica KA

2018 Jun 21;doi: 10.1039/c8cc02871k

Two-dimensional (2D) conductive metal-organic frameworks (MOFs) have emerged as a unique class of multifunctional materials due to their compositional and structural diversity accessible through bottom-up self-assembly. This feature article summarizes the progress in the development of 2D conductive MOFs with emphasis on synthetic modularity, device integration strategies, and multifunctional properties. Applications spanning sensing, catalysis, electronics, energy conversion, and storage are discussed. The challenges and future outlook in the context of molecular engineering and practical development of 2D conductive MOFs are addressed.

Chem Commun (Camb)|2018 Jun 21

Kotz D, Lord SE, O'Malley AJ, Stark L, Marsch LA

2018 Jun 20;7(6):e158doi: 10.2196/resprot.9589

Wearable and portable digital devices can support self-monitoring for patients with chronic medical conditions, individuals seeking to reduce stress, and people seeking to modify health-related behaviors such as substance use or overeating. The resulting data may be used directly by a consumer, or shared with a clinician for treatment, a caregiver for assistance, or a health coach for support. The data can also be used by researchers to develop and evaluate just-in-time interventions that leverage mobile technology to help individuals manage their symptoms and behavior in real time and as needed. Such wearable systems have huge potential for promoting delivery of anywhere-anytime health care, improving public health, and enhancing the quality of life for many people. The Center for Technology and Behavioral Health at Dartmouth College, a P30 "Center of Excellence" supported by the National Institute on Drug Abuse at the National Institutes of Health, conducted a workshop in February 2017 on innovations in emerging technology, user-centered design, and data analytics for behavioral health, with presentations by a diverse range of experts in the field. The workshop focused on wearable and mobile technologies being used in clinical and research contexts, with an emphasis on applications in mental health, addiction, and health behavior change. In this paper, we summarize the workshop panels on mobile sensing, user experience design, statistics and machine learning, and privacy and security, and conclude with suggested research directions for this important and emerging field of applying digital approaches to behavioral health. Workshop insights yielded four key directions for future research: (1) a need for behavioral health researchers to work iteratively with experts in emerging technology and data analytics, (2) a need for research into optimal user-interface design for behavioral health technologies, (3) a need for privacy-oriented design from the beginning of a novel technology, and (4) the need to develop new analytical methods that can scale to thousands of individuals and billions of data points.

JMIR Res Protoc|2018 Jun 20

Auerbach DI, Staiger DO, Buerhaus PI

2018 Jun 21;378(25):2358-2360doi: 10.1056/NEJMp1801869

N Engl J Med|2018 Jun 21

Byun J, Schwartz AG, Lusk C, Wenzlaff AS, de Andrade M, Mandal D, Gaba C, Yang P, You M, Kupert EY, Anderson MW, Han Y, Li Y, Qian D, Stilp A, Laurie C, Nelson S, Zheng W, Hung RJ, Gaborieau V, Mckay J, Brennan P, Caporaso NE, Landi MT, Wu X, McLaughlin JR, Brhane Y, Bossé Y, Pinney SM, Bailey-Wils...

2018 Jun 19;doi: 10.1093/carcin/bgy080

To identify genetic variation associated with lung cancer risk, we performed a genome-wide association analysis of 685 lung cancer cases that had a family history of two or more first or second degree relatives compared with 744 controls without lung cancer that were genotyped on an Illumina Human OmniExpressExome-8v1 array. To ensure robust results, we further evaluated these findings using data from six additional studies that were assembled through the Transdisciplinary Research on Cancer of the Lung Consortium comprising 1,993 familial cases and 33,690 controls. We performed a meta-analysis after imputation of all variants using the 1000 Genomes Project Phase 1 (version 3 release date September 2013). Analyses were conducted for 9,327,222 SNPs integrating data from the two sources. A novel variant on chromosome 4p15.31 near the LCORL gene and an imputed rare variant intergenic between CDKN2A and IFNA8 on chromosome 9p21.3 were identified at a genome-wide level of significance for squamous cell carcinomas. Additionally, associations of CHRNA3 and CHRNA5 on chromosome 15q25.1 in sporadic lung cancer were confirmed at a genome-wide level of significance in familial lung cancer. Previously identified variants in or near CHRNA2, BRCA2, CYP2A6 for overall lung cancer, TERT, SECISPB2L and RTEL1 for adenocarcinoma and RAD52 and MHC for squamous carcinoma were significantly associated with lung cancer.

Carcinogenesis|2018 Jun 19

Hao N, Nie Y, Shen T, Zhang JXJ

2018 Jun 20;doi: 10.1039/c8lc00273h

Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.

Lab Chip|2018 Jun 20

Martin IW, Atkinson AE, Liu X, Suriawinata AA, Lefferts JA, Lisovsky M

2018 Jun 19;doi: 10.1038/s41379-018-0060-4

The diagnosis of Candida esophagitis can be challenging when the epithelium containing Candida filamentous forms is not readily seen or is entirely sloughed away. Mucosal inflammation could be helpful diagnostically, if distinctive. However it is thought to be nonspecific in Candida esophagitis. The goal of this retrospective study was to identify features of mucosal inflammation helpful in alerting a pathologist to the possibility of Candida esophagitis when Candida mycelia are not readily observed. The study group consisted of 99 consecutive cases of Candida esophagitis and a control group of 64 consecutive cases of reflux esophagitis diagnosed at our institution from 2008-2016. Band-like superficial intraepithelial neutrophils and increased intraepithelial lymphocytes were observed in 75 and 67% of Candida esophagitis cases, respectively and only in 14 and 19% of reflux esophagitis cases, respectively (p < .0001). Intraepithelial lymphocytes were peripapillary or CD4-predominant in 75% of Candida esophagitis cases with increased lymphocytes, in contrast to 17% of reflux esophagitis cases (p = .0011). Concurrent presence of intraepithelial neutrophils and increased lymphocytes showed increased specificity for Candida esophagitis and was observed in 61% of patients with Candida esophagitis and only in 2% of patients with reflux esophagitis (p < .0001). In addition, superficial band-like neutrophils were observed concurrently with increased peripapillary lymphocytes or CD4-predominant lymphocytes in 35 and 50% of Candida esophagitis cases, respectively, in contrast to no reflux esophagitis cases. Basal cell hyperplasia and elongation of stromal papillae were frequent in both groups. The data suggest that when Candida microorganisms are not readily observed, concurrent presence of superficial band-like neutrophils and increased lymphocytes may be indicative of Candida etiology of active esophagitis.

Mod Pathol|2018 Jun 19

Choi K, Chen JC, Tan ASL, Soneji S, Moran MB

2018 Jun 19;pii: tobaccocontrol-2018-054363. doi: 10.1136/tobaccocontrol-2018-054363

We assessed whether receipt of coupons-via direct mail or e-mail-was prospectively related to trajectories of smoking behaviours.

Tob Control|2018 Jun 19

Roberts DW, Bravo JJ, Olson JD, Hickey WF, Harris BT, Nguyen LN, Hong J, Evans LT, Fan X, Wirth D, Wilson BC, Paulsen KD

2018 Jun 16;doi: 10.1093/ons/opy116

Three patients enrolled in a clinical trial of 5-aminolevulinic-acid (5-ALA)-induced fluorescence-guidance, which has been demonstrated to facilitate intracranial tumor resection, were found on neuropathological examination to have focal cortical dysplasia (FCD).

Oper Neurosurg (Hagerstown)|2018 Jun 16

Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan...

2018 Jun 16;doi: 10.1093/jnci/djy099

Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.

J Natl Cancer Inst|2018 Jun 16


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